Citation on PubMed Hakim A
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Prozac (Fluoxetine): Acts on serotonin reuptake only, with no dopamine reward pathway activity Produces no euphoria, no intoxication, and no recognized high at any dose Not scheduled by the DEA under any federal controlled substance classification Does not produce cravings, compulsive use, or dose-escalation behavior Has no established street value, diversion market, or documented recreational use pattern Discontinuation symptoms are mild to moderate, time-limited, and respond well to supervised tapering Opioids, Benzodiazepines, and Stimulants: Directly activate or potentiate dopamine release in the brains reward circuitry Produce rapid, intense euphoria, sedation, or stimulation that reinforces repeated use Classified as DEA Schedule II, III, or IV with strict prescribing and monitoring requirements Generate powerful cravings, compulsive drug-seeking, and escalating dose tolerance Have well-documented histories of diversion, recreational use, and abuse across populations Withdrawal can be medically dangerous, prolonged, and in some cases, life-threatening without supervision Signs of Prozac Misuse or Problematic Use While fluoxetine abuse is uncommon, it occurs most frequently in individuals with co-occurring substance use disorders or undertreated mental health conditions
